ABSTRACT
This study investigated the effect of ethanol extract of Cyperus rotundus rhizome on hyperlipidemia induced with carbimazole and cholesterol in male wister rats. Acute toxicity analysis with the Cyperus rotundus rhizome extract produced no letality even at higher doses. Hyperlipidemia was induced using 400 mg/kg cholesterol and 2 mg/kg carbimazole. The lipemic control group was administered cholesterol and carbimazole but not the normal control group. Cholesterol and carbimazole administration caused a significant (p = 0.05) increase in the Total Cholesterol, Triglyceride (TG), Low Density Lipoprotein (LDL), non-High Density Lipoprotein (non-HDL) Cholesterol and LDL/HDL ratio and a significant (p = .05) decrease in the levels of HDL cholesterol in the lipemic control when compared to the normal control. Treatment with ethanol extract of Cyperus rotundus at 250 mg/kg, 500 mg/kg and the standard hypolipidemic drug (simvastatin) at 5mg/kg significantly (p = 0.05) reduced total cholesterol, TG, LDL, LDL/HDL ratio, total non-HDL Cholesterol and also significantly (p=.05) increased the level of HDL cholesterol when compared to the non-treatment group (the lipemic control group). Results of the present study indicate that Cyperus rotundus rhizome contains principles that have hypolipidemic potentials and which compare effectively with standard clinically used therapeutic Hypolipidemic agent, simvastatin.